Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(2,3-bis(benzyloxy)phenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
2-(2,4-bis(benzyloxy)phenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
2-(2,4-dimethoxyphenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
2-(3,4-bis(benzyloxy)phenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
2-(3,4-dibutoxyphenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
2-(3,4-dihydroxyphenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
2-(3,4-diisobutoxyphenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
2-(3,4-dimethoxyphenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
2-(3,4-dipropoxyphenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
2-(3-methoxy-4-propoxyphenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
2-(4-(benzyloxy)-3-methoxyphenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
2-(4-butoxy-3-methoxyphenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
2-(4-hydroxy-3-methoxyphenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
2-(4-isobutoxy-3-methoxyphenyl)quinoline-4-carboxylic acid | - |
Homo sapiens | |
6-fluoro-2-[2-methyl-4-phenoxy-5-(propan-2-yl)phenyl]quinoline-4-carboxylic acid | i.e. C44 | Homo sapiens | |
brequinar | - |
Homo sapiens | |
leflunomide | - |
Homo sapiens | |
additional information | synthesis of a series of 2-substituted quinoline-4-carboxylic acids by Doebner reaction starting from freely available protocatechuic aldehyde and vanillin precursors. Human dihydroorotate dehydrogenase (hDHODH) is recognised as a clear molecular target for these heterocycles. All compounds are also tested for their antiproliferative potential against three cancer cells (MCF-7, A549, A375) and one normal cell line (HaCaT) to evaluate the selective cytotoxicity, overview. IC50 for cytotoxicity in in vivo assays. Molecular docking studies | Homo sapiens | |
teriflunomide | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-dihydroorotate + decylubiquinone | Homo sapiens | - |
orotate + decylubiquinol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q02127 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-dihydroorotate + decylubiquinone | - |
Homo sapiens | orotate + decylubiquinol | - |
? | |
additional information | reduction of decylubiquinone (DUQ) is stoichiometrically equivalent to reduction of 2,6-ichloroindophenol (DCIP) resulting in the decrease in absorbance at 610 nm, which is measured | Homo sapiens | ? | - |
- |
Synonyms | Comment | Organism |
---|---|---|
dihydroorotate dehydrogenase | - |
Homo sapiens |
hDHODH | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
decylubiquinone | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001 | - |
pH 8.0, 22°C | Homo sapiens | brequinar | |
0.0009 | - |
pH 8.0, 22°C | Homo sapiens | leflunomide | |
0.148 | - |
pH 8.0, 22°C | Homo sapiens | 2-(3,4-diisobutoxyphenyl)quinoline-4-carboxylic acid | |
0.153 | - |
pH 8.0, 22°C | Homo sapiens | 2-(3,4-dibutoxyphenyl)quinoline-4-carboxylic acid | |
0.268 | - |
pH 8.0, 22°C | Homo sapiens | 2-(2,3-bis(benzyloxy)phenyl)quinoline-4-carboxylic acid | |
0.27 | - |
pH 8.0, 22°C | Homo sapiens | 2-(3,4-bis(benzyloxy)phenyl)quinoline-4-carboxylic acid | |
0.34 | - |
pH 8.0, 22°C | Homo sapiens | 2-(2,4-bis(benzyloxy)phenyl)quinoline-4-carboxylic acid | |
0.34 | - |
pH 8.0, 22°C | Homo sapiens | 2-(4-butoxy-3-methoxyphenyl)quinoline-4-carboxylic acid | |
0.384 | - |
pH 8.0, 22°C | Homo sapiens | 2-(3,4-dipropoxyphenyl)quinoline-4-carboxylic acid | |
0.438 | - |
pH 8.0, 22°C | Homo sapiens | 2-(4-isobutoxy-3-methoxyphenyl)quinoline-4-carboxylic acid | |
0.449 | - |
pH 8.0, 22°C | Homo sapiens | 2-(3-methoxy-4-propoxyphenyl)quinoline-4-carboxylic acid | |
0.467 | - |
pH 8.0, 22°C | Homo sapiens | 2-(4-(benzyloxy)-3-methoxyphenyl)quinoline-4-carboxylic acid | |
0.944 | - |
pH 8.0, 22°C | Homo sapiens | 2-(4-hydroxy-3-methoxyphenyl)quinoline-4-carboxylic acid | |
1.073 | - |
pH 8.0, 22°C | Homo sapiens | 2-(3,4-dihydroxyphenyl)quinoline-4-carboxylic acid | |
1.387 | - |
pH 8.0, 22°C | Homo sapiens | 2-(3,4-dimethoxyphenyl)quinoline-4-carboxylic acid | |
2.549 | - |
pH 8.0, 22°C | Homo sapiens | 2-(2,4-dimethoxyphenyl)quinoline-4-carboxylic acid |